Les systèmes experts dans l'industrie minière : bilan de l'expérience SOUT et orientations futures

International audienceSOUT est un Systeme "Intelligent" d'Aide ä la Decision (SIAD) en matiere de choix du soutenement dans les galeries minières. Le choix d'un type de soutenement doit prendre en considération toute une série de données et satisfaire un grand nombre de contraintes ; de plus et c est un point tres important

INTERACTIVE APPLICATIONS IN A MANDATORY CONTROL COURSE

This paper describes how a mandatory control course is enhanced with interactive applications. Basic concepts of automatic control, different ways to assess performance and robustness of a controlled system, and limits of closed- loop systems are illustrated with graphics which can be manipulated directly with the mouse, letting the student acquire a deeper and broader understanding of theory. The applications, implemented with Sysquake as stand-alone programs, offer a simple user interface while supporting a wide range of problems

Use of Sysquake applications in an undergraduate control course

This paper describes how an undergraduate control course is enhanced with Sysquake interactive applications. Basic concepts in control theory, different ways to assess performance and robustness of a controlled system, and limits of closed-loop systems are illustrated with graphics which can be manipulated directly with the mouse, letting the student acquire a deeper and broader understanding of the theory. The applications, implemented with Sysquake as stand-alone programs, offer a simple user interface while supporting a wide range of problems

Incidence of Apoptosis in the Lymphoid Organs of Normal or Malaria Infected Mice is Decreased in CD18 and Urokinase - Receptor (UPAR, CD87) Deficient Mice

Incidence of apoptosis was investigated in the spleen and lymph nodes of +/+, CD18 -/- and urokinase receptor (uPAR, CD87) -/- mice, untreated or Plasmodium Berghei Anka (PbA) infected. In non infected mice, incidence of apoptosis was lower in the lymph nodes of CD18 -/- and uPAR -/- than in +/+ mice, as seen by FACS analysis to count the number of hypodiploid and Annexin-V binding cells. Infection of mice with PbA resulted in a marked increase in the size of spleen and lymph nodes 7–8 days after infection, which was slightly higher in uPAR -/- and CD18 -/- than in +/+ mice. PbA infection increased about 7 fold the incidence of apoptosis in the lymphoid organs of +/+, especially in the white pulp and germinal centers of the spleen and lymph nodes, while in contrast it was unchanged in PbA infected CD18 -/- or uPAR -/- mice. Serum IgG levels, and number of circulating leukocytes were significantly higher in both uPAR and CD18 -/- than in +/+ mice. These results indicate that the CD18 and uPAR surface molecules, which are known to be associated in the cell membrane, have an important influence upon the incidence of cell survival in both normal or stimulated lymphoid organs

New interactive books for control education

This paper presents ongoing project to develop new interactive books for control education. The novelty of the proposed idea is to merge web-based solutions with LaTex text into a epub format. In such a way, classical interactive tools for control education are combined with static text and thus interactive books are created, being compatible with standard e-book readers. A book chapter about the teaching of second-order processes is presented as example to show the different steps and the results of the proposed ideaPostprint (published version

Impact of age, leukocyte count and day 21-bone marrow response to chemotherapy on the long-term outcome of children with philadelphia chromosome-positive acute lymphoblastic leukemia in the pre-imatinib era: results of the FRALLE 93 study

<p>Abstract</p> <p>Background</p> <p>We explored the heterogeneity of philadelphia chromosome-positive acute lymphoblastic leukemia (Ph1-ALL) in a study of the effect of early features on prognosis in children. Here we report the long-term results of the FRALLE 93 study conducted in the era before the use of tyrosine kinase inhibitors.</p> <p>Methods</p> <p>Between 1993 and 1999, 36 children with Ph1-ALL were enrolled into the FRALLE 93 protocol. After conventional four-drug induction, children were stratified by availability of an HLA-matched sibling.</p> <p>Results</p> <p>Complete remission (CR) was observed in 26 children (72%), of which 13 underwent allogeneic bone marrow transplantation (BMT). Thirty-one children were good responders to prednisone, defined on day 8, and 21 were good responders to chemotherapy, defined by day-21 bone marrow (M1). Overall five-year disease-free survival (DFS) was 42 ± 9.7%. Based on multivariate analysis, two groups showed marked differences in five-year outcome: children with age<10, leukocyte count <100,000/mm³and day-21 M1 marrow had a more favorable prognosis (14 pts: 100% CR, event free survival [EFS]: 57%, overall survival [OS]: 79%), than the high-risk group (22 patients: 55% CR, EFS: 18%, OS: 27%) (p < 0.005). We also observed a non statistically significant difference (p = 0.14) in outcome between these groups for transplanted patients (5-year DFS: 83 ± 14% and 33 ± 15%, respectively).</p> <p>Conclusion</p> <p>Age, leukocyte count and early response to treatment defined by the D21 bone marrow response provide an accurate model for outcome prediction. The combination of available tools such as minimal residual disease assessment with determination of these simple factors could be useful for refining indications for BMT in the current era of tyrosine-kinase inhibitor-based therapy.</p